Calcium Channel

Channel

Ca2+ channels; Ca channels

Calcium Channel

Calcium Channel Isoform Specific Products:

Calcium Channel Related Products (886)
Antibodies (29)
Related Compound Screening Libraries (1)
Calcium Channel Isoform Comparison

By Effects:	Controls (8) Inhibitors (443) Ligands (4) Agonists (28) Antagonists (187) Activators (50) Modulators (25) Chemical (1) Inducers (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-12882A

Ifenprodil tartrate	Inhibitor	99.95%
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM). Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease.

HY-D1024

Coelenterazine h		98.80%
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca²⁺, thus providing a valuable tool for measuring small changes in Ca²⁺ concentrations.

HY-B1077

Penfluridol	Inhibitor	99.93%
Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca²⁺-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 µg/ml.

HY-148816

SG-094	Inhibitor
SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.

HY-17402

Nisoldipine	Inhibitor	99.56%
Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity.

HY-15553A

Mibefradil dihydrochloride	Inhibitor	≥98.0%
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively).

HY-N0215S12

L-Phenylalanine-d₅	Antagonist	99.90%
L-Phenylalanine-d₅ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-17404

Cilnidipine	Inhibitor	99.72%
Cilnidipine is a long-acting, second-generation dihydropyridine Ca²⁺-channel blocker on L and N-type Ca²⁺ channel. Antihypertensive effects.

HY-P10408

Candidalysin	Activator	99.38%
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

HY-50722

NNC 55-0396	Inhibitor	≥99.0%
NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC₅₀ value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research.

HY-N1584A

Halofuginone hydrobromide	Inhibitor	99.99%
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

HY-B0309

Felodipine	Inhibitor	99.83%
Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.

HY-B0233

Isradipine	Inhibitor	99.97%
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.

HY-B0280

Ranolazine	Inhibitor	99.79%
Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.

HY-B0122

Topiramate	Inhibitor	99.76%
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-N0283

Diacerein	Modulator	98.78%
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research.

HY-116330A

Hyperforin dicyclohexylammonium salt	Modulator	99.52%
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

HY-15718A

Istaroxime hydrochloride	Activator	99.32%
Istaroxime hydrochloride is a Na⁺/K⁺-ATPase inhibitor (IC₅₀=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

HY-B0405

Bupivacaine	Inhibitor	99.96%
Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain.

HY-N6778

Paxilline	Inhibitor	99.91%
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity.

Calcium Channel Blocker Library

Compound library containing a variety of calcium channel blockers and antagonists.

174compounds HY-L117

L-Ascorbic acid				T-type calcium channel		99.97%
Minocycline hydrochloride		L-type calcium channel				99.79%
L-Ascorbic acid sodium salt				T-type calcium channel		99.97%
Bay K 8644		L-type calcium channel, EC₅₀: 17.3 nM				99.96%
Ruthenium red		L-type calcium channel
Amlodipine		L-type calcium channel				99.87%
Ethacrynic acid		L-type calcium channel				99.98%
Flufenamic acid		L-type calcium channel				99.93%
Diltiazem hydrochloride		L-type calcium channel				99.47%
Nisoldipine		L-type calcium channel				99.56%
Mibefradil dihydrochloride		L-type calcium channel		T-type calcium channel		≥98.0%
Cilnidipine		L-type calcium channel				99.72%
NNC 55-0396				T-type calcium channel		≥99.0%
Felodipine		L-type calcium channel				99.83%
Isradipine		L-type calcium channel				99.97%
Diacerein		L-type calcium channel				98.78%
Urolithin C		L-type calcium channel				≥98.0%
(S)-(-)-Bay-K-8644		L-type calcium channel				99.10%
Manidipine dihydrochloride				T-type calcium channel		99.84%
Diltiazem		L-type calcium channel				99.70%
Flunarizine dihydrochloride				T-type calcium channel		99.87%
Ginsenoside Rd		L-type calcium channel				99.88%
Ziconotide acetate	N-type calcium channel					99.58%
Amlodipine besylate		L-type calcium channel				99.91%
Ethosuximide				T-type calcium channel		99.35%
5-Hydroxyindole		L-type calcium channel				99.94%
Dronedarone		L-type calcium channel				99.93%
Ulixacaltamide				T-type calcium channel		98.73%
Lacidipine		L-type calcium channel				99.79%
ML218				T-type calcium channel		99.49%
Trimethadione				T-type calcium channel		98.77%
Lomerizine dihydrochloride		L-type calcium channel		T-type calcium channel		99.84%
TTA-A2				T-type calcium channel		≥99.0%
Pinaverium bromide		L-type calcium channel				99.73%
Catharanthine		L-type calcium channel				99.65%
Ginsenoside Rf	N-type calcium channel					99.48%
(R)-(+)-Bay-K-8644		L-type calcium channel
Fluspirilene		L-type calcium channel				99.66%
Azelnidipine		L-type calcium channel				99.66%
Efonidipine hydrochloride monoethanolate		L-type calcium channel		T-type calcium channel		99.83%
Norfluoxetine hydrochloride				Ca_V3.3, IC₅₀: 5 μM		99.58%
CaV1.3 antagonist-1		Ca_V1.3, IC₅₀: 1.7 μM				98.38%
Etripamil		L-type calcium channel				98.80%
Suvecaltamide				T-type calcium channel		99.96%
Amlodipine maleate		L-type calcium channel				99.87%
1-Octanol				T-type calcium channel		99.63%
Barnidipine hydrochloride		L-type calcium channel				99.96%
ABT-639				T-type calcium channel		99.32%
Apinocaltamide		Ca_v1.2, IC₅₀: 2410 nM		Ca_V3.1, IC₅₀: 6.4 nM Ca_v3.2, IC₅₀: 18 nM Ca_V3.3, IC₅₀: 7.5 nM		99.83%
TTA-P2				T-type calcium channel Ca_v3.2		99.92%
Drotaverine hydrochloride		L-type calcium channel				99.65%
Norverapamil hydrochloride		L-type calcium channel				99.80%
Trimebutine maleate		L-type calcium channel				99.91%
GV-58	N-type calcium channel, EC₅₀: 7.21 μM		P/Q-type calcium channel, EC₅₀: 8.81 μM			99.22%
Nefiracetam	N-type calcium channel	L-type calcium channel				99.91%
SR33805		L-type calcium channel, EC₅₀: 4.1 nM (in depolarized conditions) L-type calcium channel, EC₅₀: 33 nM (in polarized conditions)				99.19%
NP118809	N-type calcium channel, IC₅₀: 0.11 μM	L-type calcium channel, IC₅₀: 12.2 μM				98.73%
Trimebutine		L-type calcium channel				99.42%
Ca2+ channel agonist 1	N-type calcium channel, EC₅₀: 14.23 μM					99.71%
SAK3				T-type calcium channel		99.80%
(2R/S)-6-PNG				T-type calcium channel		99.88%
Ethacrynic acid (Standard)		L-type calcium channel
Landiolol hydrochloride		L-type calcium channel				99.96%
IDO1-IN-19					ICa, IC₅₀: 8.3 μM	98.52%
TTA-Q6				T-type calcium channel		99.97%
Psoralenoside		L-type calcium channel				99.84%
(2R,3R)-Butane-2,3-diol					La³⁺-sensitive calcium channel, EC₅₀: 25 mM	99.17%
MMK1					Calcium Channel	99.22%
NS-638		L-type calcium channel				99.84%
Cycleanine		L-type calcium channel				99.80%
Barnidipine-d₅ hydrochloride		L-type calcium channel				≥98.0%
TTA-Q6(isomer)				T-type calcium channel		99.84%
ω-Agatoxin TK			P/Q-type calcium channel			≥99.0%
Catharanthine Tartrate		L-type calcium channel				98.88%
CXL-1020		L-type calcium channel				≥99.0%
Catharanthine Sulfate		L-type calcium channel
N-Desalkylflurazepam		Ca_v1.2, IC₅₀: 55 μM Ca_V1.3, IC₅₀: 37 μM				99.95%
Cav 2.2 blocker 2	N-type calcium channel					98.45%
Amlodipine-d₄ maleate		L-type calcium channel
Mibefradil		L-type calcium channel		T-type calcium channel
PD0176078	N-type calcium channel					99.80%
Minocycline		L-type calcium channel				98.59%
Ziconotide	N-type calcium channel
Ziconotide TFA	N-type calcium channel
Amlodipine mesylate		L-type calcium channel
Mibefradil dihydrochloride hydrate		L-type calcium channel
IAA65				T-type calcium channel
MMK1 TFA					Calcium Channel
IAB15				T-type calcium channel
MONIRO-1	hCa_v2.2, IC₅₀: 34 μM			hCa_v3.1, IC₅₀: 3.3 μM hCa_v3.2, IC₅₀: 1.7 μM hCa_v3.3, IC₅₀: 7.2 μM		99.18%
Calciseptin		L-type calcium channel, IC₅₀: 15 nM
Ethacrynic acid D5		L-type calcium channel
Calcicludine		L-type calcium channel, IC₅₀: 88 nM
Elgodipine		L-type calcium channel, IC₅₀: 2.3 nM		T-type calcium channel, IC₅₀: 32 nM
Ginsenoside Rd (Standard)		L-type calcium channel
(2R,3R)-Butane-2,3-diol (Standard)					La³⁺-sensitive calcium channel, EC₅₀: 25 mM
Cav 2.2/3.2 blocker 1	Ca_V2.2, IC₅₀: 78 μM			Ca_v3.2, IC₅₀: 80 μM
sFTX-3.3	N-type calcium channel, IC₅₀: 0.70 mM		P/Q-type calcium channel, IC₅₀: 0.24 mM
5-Hydroxyindole (Standard)		L-type calcium channel
Barnidipine		L-type calcium channel
Cavα2δ1&NET-IN-3					Calcium Channel
Cav 3.2 inhibitor 3				Ca_v3.2, IC₅₀: 0.1534 μM
Huwentoxin XVI	N-type calcium channel
Landiolol		L-type calcium channel
ILS-920		L-type calcium channel
N-Salicyloyltryptamine		L-type calcium channel
LY393615			P/Q-type calcium channel, IC₅₀: 4 μM
T-Type calcium channel inhibitor 2				Ca_V3.1, IC₅₀: 31.0 μM Ca_v3.2, IC₅₀: 83.1 μM Ca_V3.3, IC₅₀: 69.3 μM
GW7845		L-type calcium channel
Lomerizine		L-type calcium channel
GTx1-15					Calcium Channel
Diltiazem malate		L-type calcium channel
KTt-45				T-type calcium channel
Trimebutine-d₃ hydrochloride		L-type calcium channel
Diltiazem (hydrochloride) (Standard)		L-type calcium channel
AT1R antagonist 3		Ca_v1.2, Ki: 0.57 μM
Trimebutine-d₅ fumarate		L-type calcium channel
Norverapamil		L-type calcium channel
Trimebutine maleate (Standard)		L-type calcium channel
Cav 3.1 blocker 1				Ca_V3.1, IC₅₀: 160 nM Ca_v3.2, IC₅₀: 5000 nM Ca_V3.3, IC₅₀: >10000 nM Ca_V 1.2, IC₅₀: >10000 nM
Landiolol hydrochloride (Standard)		L-type calcium channel
8-Br-7-CH-cADPR					Calcium Channel
Triphenylethylene		L-type calcium channel
ABT-639 hydrochloride				T-type calcium channel
Nefiracetam (Standard)	N-type calcium channel	L-type calcium channel
Trimebutine (Standard)		L-type calcium channel

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Calcium Channel

Calcium Channel

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Specific Products:

Calcium Channel Related Products (886)

Antibodies (29)

Related Compound Screening Libraries (1)

Calcium Channel Isoform Comparison

Calcium Channel Related Products (886):