1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. Calcium Channel

Calcium Channel

Channel

Ca2+ channels; Ca channels

Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148816
    SG-094
    Inhibitor
    SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.
    SG-094
  • HY-15553A
    Mibefradil dihydrochloride
    Inhibitor ≥98.0%
    Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively).
    Mibefradil dihydrochloride
  • HY-B1077
    Penfluridol
    Inhibitor 99.93%
    Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 µg/ml.
    Penfluridol
  • HY-17402
    Nisoldipine
    Inhibitor 99.56%
    Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity.
    Nisoldipine
  • HY-D1024
    Coelenterazine h
    98.80%
    Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca2+, thus providing a valuable tool for measuring small changes in Ca2+ concentrations.
    Coelenterazine h
  • HY-N0215S12
    L-Phenylalanine-d5
    Antagonist 99.90%
    L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
    L-Phenylalanine-d<sub>5</sub>
  • HY-17404
    Cilnidipine
    Inhibitor 99.72%
    Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel. Antihypertensive effects.
    Cilnidipine
  • HY-N1584A
    Halofuginone hydrobromide
    Inhibitor 99.99%
    Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
    Halofuginone hydrobromide
  • HY-B0280
    Ranolazine
    Inhibitor 99.79%
    Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
    Ranolazine
  • HY-B0309
    Felodipine
    Inhibitor 99.83%
    Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.
    Felodipine
  • HY-116330A
    Hyperforin dicyclohexylammonium salt
    Modulator 99.52%
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin dicyclohexylammonium salt
  • HY-15718A
    Istaroxime hydrochloride
    Activator 99.32%
    Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
    Istaroxime hydrochloride
  • HY-N0283
    Diacerein
    Modulator 98.78%
    Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research.
    Diacerein
  • HY-B0233
    Isradipine
    Inhibitor 99.97%
    Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
    Isradipine
  • HY-B0122
    Topiramate
    Inhibitor ≥98.0%
    Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate
  • HY-50722
    NNC 55-0396
    Inhibitor ≥99.0%
    NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research.
    NNC 55-0396
  • HY-B0405
    Bupivacaine
    Inhibitor 99.96%
    Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
    Bupivacaine
  • HY-P10408
    Candidalysin
    Activator 99.38%
    Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity
    Candidalysin
  • HY-N6778
    Paxilline
    Inhibitor 99.83%
    Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity.
    Paxilline
  • HY-15124
    (S)-(-)-Bay-K-8644
    Agonist 98.81%
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).
    (S)-(-)-Bay-K-8644
Cat. No. Product Name / Synonyms Application Reactivity

N-type calcium channel

L-type calcium channel

P/Q-type calcium channel

T-type calcium channel

Calcium Channel

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Calcium Channel Controls, Inhibitors, Agonists, Antagonists, Activators & Modulators
Product NameN-type calcium channelL-type calcium channelP/Q-type calcium channelT-type calcium channelCalcium ChannelPurity    
L-Ascorbic acid   
T-type calcium channel
 99.97%
Minocycline hydrochloride 
L-type calcium channel
   99.79%
L-Ascorbic acid sodium salt   
T-type calcium channel
 99.97%
Bay K 8644 
L-type calcium channel, EC50: 17.3 nM
   99.96%
Ruthenium red 
L-type calcium channel
   
Amlodipine 
L-type calcium channel
   99.87%
Ethacrynic acid 
L-type calcium channel
   99.98%
Flufenamic acid 
L-type calcium channel
   99.93%
Diltiazem hydrochloride 
L-type calcium channel
   99.04%
Mibefradil dihydrochloride 
L-type calcium channel
 
T-type calcium channel
 ≥98.0%
Nisoldipine 
L-type calcium channel
   99.56%
Cilnidipine 
L-type calcium channel
   99.72%
Felodipine 
L-type calcium channel
   99.83%
Diacerein 
L-type calcium channel
   98.78%
Isradipine 
L-type calcium channel
   99.97%
NNC 55-0396   
T-type calcium channel
 ≥99.0%
(S)-(-)-Bay-K-8644 
L-type calcium channel
   98.81%
Urolithin C 
L-type calcium channel
   ≥98.0%
Manidipine dihydrochloride   
T-type calcium channel
 99.91%
Diltiazem 
L-type calcium channel
   99.70%
Flunarizine dihydrochloride   
T-type calcium channel
 99.87%
Ginsenoside Rd 
L-type calcium channel
   99.88%
Amlodipine besylate 
L-type calcium channel
   99.91%
5-Hydroxyindole 
L-type calcium channel
   99.94%
Ethosuximide   
T-type calcium channel
 99.35%
Ziconotide acetate
N-type calcium channel
    99.58%
Dronedarone 
L-type calcium channel
   99.93%
Ulixacaltamide   
T-type calcium channel
 98.73%
ML218   
T-type calcium channel
 99.49%
Lomerizine dihydrochloride 
L-type calcium channel
 
T-type calcium channel
 99.84%
TTA-A2   
T-type calcium channel
 ≥99.0%
Pinaverium bromide 
L-type calcium channel
   99.73%
Lacidipine 
L-type calcium channel
   99.79%
Catharanthine 
L-type calcium channel
   99.65%
Trimethadione   
T-type calcium channel
 98.77%
(R)-(+)-Bay-K-8644 
L-type calcium channel
   
Fluspirilene 
L-type calcium channel
   99.66%
Efonidipine hydrochloride monoethanolate 
L-type calcium channel
 
T-type calcium channel
 99.83%
Azelnidipine 
L-type calcium channel
   99.66%
Ginsenoside Rf
N-type calcium channel
    99.48%
Norfluoxetine hydrochloride   
CaV3.3, IC50: 5 μM
 99.58%
CaV1.3 antagonist-1 
CaV1.3, IC50: 1.7 μM
   98.38%
Suvecaltamide   
T-type calcium channel
 99.96%
Etripamil 
L-type calcium channel
   98.80%
1-Octanol   
T-type calcium channel
 99.63%
Amlodipine maleate 
L-type calcium channel
   99.87%
Barnidipine hydrochloride 
L-type calcium channel
   99.96%
ABT-639   
T-type calcium channel
 99.32%
Apinocaltamide 
Cav1.2, IC50: 2410 nM
 
CaV3.1, IC50: 6.4 nM
Cav3.2, IC50: 18 nM
CaV3.3, IC50: 7.5 nM
 99.83%
Drotaverine hydrochloride 
L-type calcium channel
   99.65%
Norverapamil hydrochloride 
L-type calcium channel
   99.80%
GV-58
N-type calcium channel, EC50: 7.21 μM
 
P/Q-type calcium channel, EC50: 8.81 μM
  99.22%
Nefiracetam
N-type calcium channel
L-type calcium channel
   99.91%
NP118809
N-type calcium channel, IC50: 0.11 μM
L-type calcium channel, IC50: 12.2 μM
   98.73%
SR33805 
L-type calcium channel, EC50: 4.1 nM (in depolarized conditions)
L-type calcium channel, EC50: 33 nM (in polarized conditions)
   99.19%
Ca2+ channel agonist 1
N-type calcium channel, EC50: 14.23 μM
    99.71%
SAK3   
T-type calcium channel
 99.80%
(2R/S)-6-PNG   
T-type calcium channel
 99.88%
Landiolol hydrochloride 
L-type calcium channel
   99.96%
IDO1-IN-19    
ICa, IC50: 8.3 μM
98.52%
TTA-Q6   
T-type calcium channel
 99.97%
Psoralenoside 
L-type calcium channel
   99.84%
Ethacrynic acid (Standard) 
L-type calcium channel
   
(2R,3R)-Butane-2,3-diol    
La3+-sensitive calcium channel, EC50: 25 mM
99.17%
NS-638 
L-type calcium channel
   99.84%
MMK1    
Calcium Channel
99.22%
Cycleanine 
L-type calcium channel
   99.80%
Barnidipine-d5 hydrochloride 
L-type calcium channel
   ≥98.0%
TTA-Q6(isomer)   
T-type calcium channel
 99.84%
ω-Agatoxin TK  
P/Q-type calcium channel
  ≥99.0%
Catharanthine Tartrate 
L-type calcium channel
   98.88%
CXL-1020 
L-type calcium channel
   ≥99.0%
Catharanthine Sulfate 
L-type calcium channel
   
N-Desalkylflurazepam 
Cav1.2, IC50: 55 μM
CaV1.3, IC50: 37 μM
   99.95%
Cav 2.2 blocker 2
N-type calcium channel
    98.45%
Amlodipine-d4 maleate 
L-type calcium channel
   
Mibefradil 
L-type calcium channel
 
T-type calcium channel
 
Minocycline 
L-type calcium channel
   
Ziconotide
N-type calcium channel
    
Ziconotide TFA
N-type calcium channel
    
Amlodipine mesylate 
L-type calcium channel
   
Mibefradil dihydrochloride hydrate 
L-type calcium channel
   
IAA65   
T-type calcium channel
 
MMK1 TFA    
Calcium Channel
IAB15   
T-type calcium channel
 
MONIRO-1
hCav2.2, IC50: 34 μM
  
hCav3.1, IC50: 3.3 μM
hCav3.2, IC50: 1.7 μM
hCav3.3, IC50: 7.2 μM
 99.18%
Calciseptin 
L-type calcium channel, IC50: 15 nM
   
Ethacrynic acid D5 
L-type calcium channel
   
Calcicludine 
L-type calcium channel, IC50: 88 nM
   
Elgodipine 
L-type calcium channel, IC50: 2.3 nM
 
T-type calcium channel, IC50: 32 nM
 
Ginsenoside Rd (Standard) 
L-type calcium channel
   
(2R,3R)-Butane-2,3-diol (Standard)    
La3+-sensitive calcium channel, EC50: 25 mM
Cav 2.2/3.2 blocker 1
CaV2.2, IC50: 78 μM
  
Cav3.2, IC50: 80 μM
 
sFTX-3.3
N-type calcium channel, IC50: 0.70 mM
 
P/Q-type calcium channel, IC50: 0.24 mM
  
5-Hydroxyindole (Standard) 
L-type calcium channel
   
Barnidipine 
L-type calcium channel
   
Cavα2δ1&NET-IN-3    
Calcium Channel
Cav 3.2 inhibitor 3   
Cav3.2, IC50: 0.1534 μM
 
Huwentoxin XVI
N-type calcium channel
    
Landiolol 
L-type calcium channel
   
ILS-920 
L-type calcium channel
   
N-Salicyloyltryptamine 
L-type calcium channel
   
LY393615  
P/Q-type calcium channel, IC50: 4 μM
  
T-Type calcium channel inhibitor 2   
CaV3.1, IC50: 31.0 μM
Cav3.2, IC50: 83.1 μM
CaV3.3, IC50: 69.3 μM
 
GW7845 
L-type calcium channel
   
Lomerizine 
L-type calcium channel
   
GTx1-15    
Calcium Channel
Diltiazem malate 
L-type calcium channel
   
KTt-45   
T-type calcium channel
 
Diltiazem (hydrochloride) (Standard) 
L-type calcium channel
   
AT1R antagonist 3 
Cav1.2, Ki: 0.57 μM
   
Norverapamil 
L-type calcium channel
   
Cav 3.1 blocker 1   
CaV3.1, IC50: 160 nM
Cav3.2, IC50: 5000 nM
CaV3.3, IC50: >10000 nM
CaV 1.2, IC50: >10000 nM
 
Landiolol hydrochloride (Standard) 
L-type calcium channel
   
8-Br-7-CH-cADPR    
Calcium Channel
Triphenylethylene 
L-type calcium channel
   
ABT-639 hydrochloride   
T-type calcium channel
 
Nefiracetam (Standard)
N-type calcium channel
L-type calcium channel
   
PD0176078
N-type calcium channel
    99.80%